Phenotypic and antigenic variation of Mycoplasma Gallisepticum vaccine strains

Antigenic variation between rabies virus strains and its relevance in vaccine production and potency testing

Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum.

Mycoplasma gallisepticum is a significant respiratory and reproductive pathogen of domestic poultry. While the complete genomic sequence of the virulent, low-passage M. gallisepticum strain R (R(low)) has been reported, genomic determinants responsible for differences in virulence and host range remain to be completely identified. Here, we utilize genome sequencing and microarray-based comparat...

Molecular characterization of Mycoplasma gallisepticum strains from South African poultry

This dissertation is dedicated to my parents Mamatsaba and Ohentse, my siblings Lerato and Lebogang, my cousin siblings Diau, Keneilwe, Ntsane and my grandmother Sponkie. 2 Acknowledgements I would like to express my deepest gratitude to the following: God, for I am a product of his mercy and love. This has been a successful year and I know I could not have done it alone. Thank you Father. Prof...

Proteomic Analysis of Mycoplasma gallisepticum Vaccine Strain F

The persistence and displacement abilities of the Mycoplasma gallisepticum vaccine strain F (F-strain) are well documented. Understanding the mechanism(s) of colonization and persistence of F-strain will aid in the current intervention strategies to diagnose and control MG infections in poultry. In the present study, phase partition and liquid chromatography along with electrospray mass spectro...

pMGA phenotypic variation in Mycoplasma gallisepticum occurs in vivo and is mediated by trinucleotide repeat length variation.

Chickens were infected with a pathogenic strain of Mycoplasma gallisepticum, and the expression of pMGA, the major surface protein, was inferred by examination of colonies from ex vivo cells. Within 2 days postinfection, 40% of cells had ceased the expression of the original pMGA surface protein (pMGA1.1), and by day 6, the majority of recovered cells were in this category. The switch in pMGA p...